Abstract
The natural course of amyloid deposition in the human brain has not been established. We measured change in brain amyloid deposition over time in healthy elderly persons, patients with mild cognitive impairment (MCI), and Alzheimer's disease (AD) using [11C]PIB PET. Eleven healthy volunteers (HV, 67 ± 6 years; MMSE scores: 28.4 ± 1.6), 10 patients with MCI (76 ± 5 years; MMSE scores: 26.9± 1.4), and 8 patients with AD (69 ± 8 years of age; MMSE scores: 20.6 ± 4.0) participated in this study. The subjects were studied twice at the baseline and the follow-up study with a mean interval of 2 years. Following intravenous injection of [11C]PIB (about 370 MBq), 19 sequential PET scans were performed for a period of 90 min. PET images were co-registered to MRI in each subject. Volume of interests were placed manually on bilateral frontal, temporal, parietal, anterior and posterior cingulate cortices, and cerebellar cortex on MRI, and these VOIs were transferred to co-registered PET images. The distribution volume ratio (DVR) of each target VOI to cerebellar cortical VOI was calculated in non-invasive Logan plot. Cortical DVR was calculated as a mean DVR value in bilateral frontal, temporal, parietal, anterior and posterior cingulated cortices. Cortical DVR was higher in AD group (Baseline: 1.73±0.18, Follow-up:1.82±0.13) than MCI group (1.21±0.24, 1.26±0.28) and HVs (1.09±0.09, 1.13±0.06) both in the baseline study and follow up study (p < 0.001). Cortical DVR was elevated by 1.8%/ year (0.48 unit) in the whole subjects including AD and MCI patients and HVs (p < 0.02, paired t-test). There was no difference in increase of cortical DVR among AD and MCI groups and HVs. Our result is in accord with the previous longitudinal [11C]PIB PET study in HVs, MCI, and AD [1], and suggest a constant slow rate of amyloid deposition in elderly persons, MCI and AD patients. [1] Jack CR, et al. Brain 2009:132;1355-1365.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
