Abstract
The oxidative stress hypothesis of aging predicts that cells of long‐lived species exhibit superior resistance to oxidative stress. We tested this hypothesis using two taxonomically related rodents, the white‐footed mouse (Peromyscus leucopus) and the house mouse (Mus musculus) that show a more than two‐fold difference in maximum lifespan potential (8.2 and 3.5 years, respectively). In P.leucopus aortas steady‐state endothelial O2.‐ and H2O2 production and ROS generation by mitochondria were less than in M.musculus vessels. Furthermore, vessels of P.leucopus were more resistant to the pro‐oxidant effects of HG. In M.musculus arteries HG elicited significant up‐regulation of inflammatory markers (TNFá, IL‐6, ICAM‐1, VCAM and MCP‐1). In contrast, the pro‐inflammatory effects of HG were blunted in P.leucopus vessels. Thus, increased lifespan potential in P.leucopus is associated with a decreased cellular ROS generation and increased resistance to the pro‐oxidant and pro‐inflammatory effects of metabolic stress, which accord with the predictions of the oxidative stress hypothesis of aging
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
