Abstract
Methods In a prospective study, a cohort of select seropositive drug naive subjects is being monitored at YRG CARE, Chennai for a period of two years with repeated sampling at 6-month intervals. The viral RNA was extracted from plasma and Gag was amplified, followed by Sanger sequencing. The samples of interest were further subjected to next-generation sequencing using Illumina MiSeq and analyzed using the CLC Genomics Workbench software.
Highlights
HIV-1 is capable of evading the CTL immune response by introducing mutations in residues both within the epitopes and in sequences flanking the epitopes
The present study aims at identifying the mechanisms of CTL immune escape primarily in the asymptomatic phase of HIV-1 subtype C in drug naive patients from an Indian clinical cohort
Submit your manuscript to BioMed Central and take full advantage of: Conclusion The preliminary data suggest that subtype C is capable of causing sequence insertions of longer length in the PTAP domain of the p6 gag, unlike other viral subtypes that insert sequences of shorter length at this location
Summary
Longer sequence insertions in p6 gag play a role in immune escape in HIV-1 subtype C. Shilpee Sharma[1], GA Shambhu Prasad[1], Ravi Vijaya Satya[2], Viswanath Ragupathy[3], Shanmugam Saravanan[4], Kailapuri G Murugavel[4], Pachamuthu Balakrishnan[4], Suniti Solomon[4], Indira Hewlett[3], Udaykumar Ranga1*. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. 30 January - 1 February 2014
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