Long time dynamics of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects

Abstract

<p style='text-indent:20px;'>We consider a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects which is introduced in [<xref ref-type="bibr" rid="b2">2</xref>]. It is comprised of phase-field equation to describe tumor growth, which is coupled to a reaction-diffusion type equation for generic nutrient for the tumor. An additional equation couples the concentration of prostate-specific antigen (PSA) in the prostatic tissue and it obeys a linear reaction-diffusion equation. The system completes with homogeneous Dirichlet boundary conditions for the tumor variable and Neumann boundary condition for the nutrient and the concentration of PSA. Here we investigate the long time dynamics of the model. We first prove that the initial-boundary value problem generates a strongly continuous semigroup on a suitable phase space that admits the global attractor in a proper phase space. Moreover, we also discuss the convergence of a solution to a single stationary state and obtain a convergence rate estimate under some conditions on the coefficients.</p>