Long-Term Use of Oral Bisphosphonates and Fracture Risk in Men with Traumatic Spinal Cord Injury

Ludovico Carbone ,B Catharine Craven ,Scott Miskevics ,Bella Etingen ,Marylou Guihan ,Cara Ray ,Beverly Gonzalez ,Frances M Weaver

doi:10.33696/rehabilitation.2.013

Ludovico Carbone , B Catharine Craven + Show 6 more

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https://doi.org/10.33696/rehabilitation.2.013

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Abstract

Long-Term Use of Oral Bisphosphonates and Fracture Risk in Men with Traumatic Spinal Cord Injury

Highlights

Lower extremity fractures in individuals with a spinal cord injury (SCI) cause significant morbidity [1] and contribute to excess mortality [2]
We identified 7,989 male Veterans with a traumatic SCI who had utilized Veterans Health Administration (VHA) health care between fiscal years (FY) 2010-2015 after applying the exclusions noted above
There was no significant association of long-term use of oral bisphosphonates and incident lower extremity (LE) fracture (HR 0.97 [95% CI 0.25 to 3.75]) (Figure 1)

Summary

Introduction

Lower extremity fractures in individuals with a spinal cord injury (SCI) cause significant morbidity [1] and contribute to excess mortality [2]. A recent study reported that providers who care for patients with a SCI do utilize these BMD-related and clinical risk factors to identify subgroups of patients at highest risk for these events and to target pharmacological therapies for fracture prevention [6]. There are substantial differences in the pathophysiology of SCI-related bone loss compared with senile or postmenopausal osteoporosis [7,8,9] It is not clear whether pharmacological therapies that are efficacious to treat senile osteoporosis and prevent fractures in the able-bodied population [10,11,12] are effective in sublesional osteoporosis. The goal of the current analysis was to examine the association of duration of use of oral bisphosphonates with risk of lower extremity (LE) fractures in male Veterans with a SCI.

Methods

Results

Conclusion