Abstract
Introduction and Aim of work Literature suggest that antipsychotic medications may decrease cortisol level, an effect that seems to be more present with second generation antipsychotic. Our study aims at assessing effect of long term use of antipsychotics on cortisol level Subjects and Methods 30 chronic schizophrenic patients on antipsychotics compared to 20 drug naif schizophrenic patients as regards serum cortisol level Results Cortisol level was significantly lower in chronic schizophrenic patients receiving antipsychotics compared to drug naif patients (P=0.002 Conclusion Antipsychotic medications seem to have the potential to decrease cortisol level in blood. Among hypothesis proposed in literature is the good control of pseudo stress due to psychotic features
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