Long-term update of a prospective randomized trial of combined-modality therapy versus chemotherapy in advanced Hodgkin’s disease

Abstract

Purpose/Objective: The role of consolidation radiotherapy (RT) in the treatment of advanced Hodgkin’s disease (HD) is controversial. Several randomized trials have addressed this issue with contradictory results. The follow-up in these trials has generally been short and questions have often been raised concerning protocol violations, specifically adherence to radiotherapy guidelines. This paper presents long-term results of a prospective randomized trial of consolidation radiotherapy in advanced HD carried out at Duke University Medical Center.