Abstract
Long-term treatment with dimethylthiourea (DMTU), a scavenger of hydroxyl radical (.OH) and hypochlorous acid (HOCl), suppressed the age-related development of autoimmune disease in NZB x NZWF1 mice. Treatment reduced autoantibody production, retarded increase in blood urea nitrogen, and prolonged life. The results suggest that .OH and HOCl may, at least in part, enhance the development of autoimmune diseases in NZB x NZWF1 mice.
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