Long-term treatment with cholinesterase inhibitors restores homeostatic levels of calcium-independent PLA2: Evidence of disease-modification in Alzheimer's disease

Abstract

both size and color represented percent differences in metabolite levels were easily distinguished across study groups. Edges were directional and displayed as arrows where size represented percent difference in flux and color the difference in expression level across study groups. Colors ranged from green for decreases to brown for zero and orange to red for increases. Pathways had to be mapped separately and some split in order to allow visual analyses. Figure 1 shows the cholesterol pathway comparing the aged with youngest group; note how easily one can assess the extent of decrease in all metabolites and fluxes. Also note how even in cases of increased gene expression (red arrows) flux was low because the substrates were low. Export of maps into image files allowed assembly of Powerpoint slides for film-strip inspections of pathway changes. Conclusions: These results demonstrate the value of flux and metabolite pathway mapping, especially with integrating gene expression changes. Such complete pathway mapping is only.