Abstract
Sorbic acid was given to groups of 48 male and 50 female mice at dietary levels of 0 (control), 1. 5 or 10% for 80 wk. Treatment had no adverse effect on the number of deaths or the incidence of histological lesions, including tumours. Compared with the controls, there were slightly lower body weights in mice given 10% sorbic acid, increased relative kidney weights at the two higher levels and increased relative liver weights at all treatment levels. The last finding and the isolated differences in the haematological examinations were not considered to represent adverse effects. It is concluded that dietary levels of sorbic acid up to 10% did not exert any carcinogenic effect and that the no-untoward-effect level was 1% of the diet.
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