Abstract
BackgroundRecently, laparoscopic resection for relatively small sized gastric gastrointestinal stromal tumors (GISTs) has been widely accepted as minimally invasive surgery. However, no report on the long-term safety and efficacy of this surgery for large sized gastric GISTs has been published to date.MethodsBetween July 1998 and January 2011, 104 consecutive patients who underwent resection for gastric GISTs were enrolled in this retrospective study. We assessed the clinicopathological characteristics, postoperative outcomes, patient survival, and tumor recurrence.ResultsOf the 104 patients with gastric GISTs who were included in the study, there were 47 males and 57 females whose mean age was 59.8 years. Sixty-four patients (61.5%) had symptoms associated with tumor. Ten patients included in the group 1, 49 in the group 2, 15 in the group 3a, 9 in the group 5, 14 in the group 6a, and 7 in the group 6b. There was one minor complication and no mortalities. Recurrence was noted in 5 patients, with a median follow-up period of 49.3 months (range, 8.4 to 164.4). The 5-year overall and disease free survival rates of 104 patients were 98.6% and 94.8%, respectively. When comparing large tumor (5–10 cm) between laparoscopic and open surgery, there were statistically differences in age, tumor size, tumor location, and length of hospitalization. There were no statistical differences in the 5-year survival rate between laparoscopic and open surgery for large tumor (5-10cm).ConclusionLaparoscopic surgery is feasible and effective as an oncologic treatment of gastric GISTs. Moreover, laparoscopic surgery can be an acceptable alternative to open methods for gastric GISTs of size bigger than 5 cm.
Highlights
Laparoscopic resection for relatively small sized gastric gastrointestinal stromal tumors (GISTs) has been widely accepted as minimally invasive surgery
We present a retrospective review evaluating the clinicopathological characteristics, postoperative outcomes, patient survival, and tumor recurrence of gastric GISTs after surgical treatment
Patients’ evaluation and work up We reviewed the medical records of 104 patients with gastric GISTs who underwent curative resection in Dong-A University College of Medicine between July 1998 and January 2011
Summary
Laparoscopic resection for relatively small sized gastric gastrointestinal stromal tumors (GISTs) has been widely accepted as minimally invasive surgery. No report on the long-term safety and efficacy of this surgery for large sized gastric GISTs has been published to date. Gastrointestinal stromal tumors (GISTs) represent a rare but distinct histopathological group of intestinal neoplasms of mesenchymal origin. Their incidence is only 0.2% of all gastrointestinal malignancies [1]. Despite the development of a new chemotherapeutic agent, imatinib mesylate, surgery remains the only curative treatment for non-metastatic gastric GIST [2]. Lymphadenectomy is not necessary, because gastric GISTs rarely metastasize to the lymph node [3].
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