Long-term survival in patients undergoing drug-eluting stent PCI of the unprotected left main coronary artery according to renal function; Milan and New-Tokyo (MITO) registry

Abstract

Aim: There is little available data regarding the long term follow-up of patients treated with drug-eluting stent (DES) on the Unprotected Left Main (ULM) according to estimated GFR (e-GFR). Methods and results: All 1052 consecutive patients treated with DES implantation for ULM stenosis between April 2005 and August 2011 were retrospectively assessed for impact of renal function. The patients were classified into severe (e-GFR<15), moderate (15<30), mild (30<60) and normal renal function (60<) groups (59, 41, 366 and 586 patients respectively). All death and cardiac death at 5-years was as follows; 67.1%, 50.3%, 20.3% and 9.3% and 44.9%, 22.0%, 9.7% and 3.4%, respectively (Figure 1). An estimated GFR was strongly associated with all death (adjusted HR 0.981; 95% CI 0.971-0.991, p=0.01) and cardiac-death (adjusted HR 0.973; 95% CI 0.959-0.986, p=0.01). ![Figure][1] Figure 1 Conclusions: Estimated GFR seem to predict the outcome in patients undergoing PCI with DES for ULM disease. [1]: pending:yes