Abstract
Ultracentrifugal serum protein analyses were performed repeatedly during a three year study on untreated hyperglobulinaemic sheep affected with pulonary adenomatosis or other chronic pulmonary disease. Chronic pulmonary disease was associated with persistent hyper-7S-immunoglobulinaemia; sheep affected with pulmonary adenomatosis showed 78-immunoglobulin levels ranging from normal to very high. Foetuses developing in hyperglobulinaemic ewes had a normal serum protein pattern which, in the ultracentrifugal analysis, was composed of the A (4.5S) fraction only. The G (7S) fraction appeared after colostrum consumption and remained relatively low for several months until the normal adult ovine serum 7S-immunoglobulin level was reached.
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