Abstract
PURPOSE: Inhaled cyclosporin has been shown to improve survival and chronic rejection free survival in lung transplant recipients (NEJM 2006;345:141–50). Tacrolimus, another calcineurin inhibitor, has been shown to be 10–100 times more potent than cyclosporin. The purpose of this study was to evaluate the long-term safety of inhaled nanoparticles of tacrolimus in a rat model.
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