Abstract
Aim: This retrospective, observational study evaluated the long-term (>12months) safety and effectiveness of bisphosphonate. Methods: Data collected for 359 patients included quantity and proportion of adverse events (AEs) and skeletal-related events (SREs), and times to first AE and first SRE. Results: Patients in the ≤24-month group experienced significantly fewer AEs compared with the >24-month treatment group (p=0.008), and treatment for >24 months was a potential risk factor for AEs (p=0.05). Neither the proportion nor the risk of SRE was significantly associated with therapy duration (p=0.525 and 0.084, respectively). Conclusion: Bisphosphonate treatment beyond 2 years may increase the risk of AEs, but may prolong SRE-free survival early after 24months, compared with medication administered for ≤24months.
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