Abstract
Despite increasing knowledge gained based on multidisciplinary research, plasma medicine still raises various questions regarding specific effects as well as potential risks. With regard to significant statements about in vivo applicability that cannot be prognosticated exclusively based on in vitro data, there is still a deficit of clinical data. This study included a clinical follow-up of five probands who had participated five years previously in a study on the influence of cold atmospheric pressure plasma (CAP) on the wound healing of CO2 laser-induced skin lesions. The follow-up included a complex imaging diagnostic involving dermatoscopy, confocal laser scanning microscopy (CLSM) and hyperspectral imaging (HSI). Hyperspectral analysis showed no relevant microcirculatory differences between plasma-treated and non-plasma-treated areas. In summary of all the findings, no malignant changes, inflammatory reactions or pathological changes in cell architecture could be detected in the plasma-treated areas. These unique in vivo long-term data contribute to a further increase in knowledge about important safety aspects in regenerative plasma medicine. However, to confirm these findings and secure indication-specific dose recommendations, further clinical studies are required.
Highlights
The use of cold atmospheric pressure plasma (CAP) for biomedical applications is the key element of plasma medicine [1]
Index values measured for NIR and Tissue Water Index (TWI) showed intraindividual swings up to 13 index points and interindividual differences up to 19 index points (Tables 2–6)
Microcirculatory parameters showed no causal relation to the plasma-treated areas, but seemed to follow anatomical conditions and structures
Summary
The use of cold atmospheric pressure plasma (CAP) for biomedical applications is the key element of plasma medicine [1]. This field of research, which is characterized by a high degree of interdisciplinarity and is located at the interface between natural and life sciences, has been attracting increasing scientific attention for several years [2]. Depending on the plasma source, the elements of this "cocktail" are differently effective and can act as a combination of several therapeutic approaches Both physiological and pathological cellular and subcellular processes communicate via ROS and RNS and can be influenced or controlled by these effectors.
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