Abstract
Although ganglion cell inner plexiform layer (GC-IPL) analysis in the patients with high myopia is useful, there have been few reports to analyze of the reliability for long-term measured GC-IPL thickness. We aimed to analyze the long-term reproducibility of thickness measurements of the GC-IPL using spectral-domain optical coherence tomography (SD-OCT) in patients with high myopia and identify factors that affect such reproducibility. 99 eyes from 99 patients with high myopia without any other ophthalmc disorder such as glaucoma or retinal diseases were included. Two serial SD-OCT (Cirrus-HD) macular scans taken at ≧1 year intervals were analyzed. The intraclass correlation coefficient (ICC), coefficient of variation (CV), and test-retest standard deviation (TRTSD) of GC-IPL thickness measurements were assessed. The ICC, CV, and TRTSD of the mean GC-IPL thicknesses were 0.883, 5.9%, and 2.74, respectively. The ICCs of the six-sector GC-IPL thicknesses ranged from 0.740 to 0.904. The CVs of the minimal and all sectoral GC-IPL thicknesses were <10%. Measurement variances for the mean GC-IPL thicknesses showed significant relationshiups with chorioretinal atrophy and posterior staphyloma. There is high long-term reproducibility in GC-IPL thickness measurements using SD-OCT in high-myopia patients. The factors affecting this reproducibility include chorioretinal atrophy and posterior staphyloma.
Highlights
High myopia is one of the most common causes of visual loss, and is especially prevalent in Asia
Saw et al stated that highly myopic patients without other ophthalmic diseases should not be overlooked because a more severe form of myopia can lead to a greater risk of glaucoma, retinal detachment, chorioretinal atrophy, and lacquer cracks[11]
Using spectraldomain optical coherence tomography (SD-OCT), Lam et al reported that the fovea could be flattened in high-myopia patients, which is likely to be a presymptom of vitreoretinal traction[12]
Summary
High myopia is one of the most common causes of visual loss, and is especially prevalent in Asia. The Tajimi Study reported that myopic macular degeneration is the most common cause of binocular and monocular blindness in Japan[5], and Xu et al reported that pathological myopia is the second most common cause of low vision and blindness in Chinese people ≥40 years of age[6] This is because the fiber diameter is small and histologically immature in a highly myopic eye, so that chorioretinal atrophy, choroidal neovascularization, and macular retinoschisis may develop as the structure of the highly myopic eye continuously expands and is made thinner by fewer cross-linkages when compared with an emmetropic eye[7,8,9]. We determined the long-term reproducibility of GCIPL thickness measurements by SD-OCT in high-myopia patients, and identified factors that affected the reproducibility
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