Abstract
Purpose: The concentration of articular cartilage blood markers and their load induced changes can serve as surrogate parameter for investigating articular cartilage metabolism and may be useful for detecting early changes in cartilage homeostasis and ultimately predicting future structural change. One of these markers is serum cartilage oligomeric matrix protein (sCOMP), a cartilage constituent that is involved in collagen fibril organization and may represent cartilage turnover or degeneration.
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