Abstract
BackgroundPlacental site trophoblastic tumor (PSTT) is a rare and unique form of gestational trophoblastic disease (GTD). This tumor represents a neoplastic transformation of intermediate trophoblastic cells. We document a case of long term remission in a patient with metastatic PSTT.Case presentaionA 27-year-old patient with metastatic PSTT was treated with combination therapy (chemotherapy and surgery). Patient is alive after 10 years without any evidence of recurrence. Literature on PSTT was searched using Medline and cross references, and pertinent articles were reviewed.ConclusionWith surgery and chemotherapy it is possible to achieve long-term remission in metastatic PSTT. Only a handful of previously reported cases with prolonged remission had been treated with the described combined chemotherapy and surgical approach. We suggest that this approach may be recommended for metastatic PSTT.
Highlights
Placental site trophoblastic tumor (PSTT) is a rare and unique form of gestational trophoblastic disease (GTD)
A handful of previously reported cases with prolonged remission had been treated with the described combined chemotherapy and surgical approach
We suggest that this approach may be recommended for metastatic PSTT
Summary
PSTT is a disorder of uncertain outcome, some of the patients do well while others have poor outcome. Multiple courses of combined chemotherapy may be necessary for remission
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