Abstract
The role of intracellular calcium in an APV-insensitive form of long-term potentiation (LTP) has been studied at the hippocampal mossy fiber synapse. Intracellular calcium was buffered by iontophoretic injection of either BAPTA or QUIN-2, into CA3 pyramidal neurons. The slow calcium-dependent after hyperpolarization was used as an indicator of buffering. UP was elicited in control and in APV-treated cells ( 6 6 and 4 5 cell, respectively). In contrast, UP was observed in only 2 9 BAPTA-loaded cells and in 1 4 QUIN-2-loaded cells. The magnitude of UP for control and APV treated cells were not significantly different, but both groups showed significantly greater UP than BAPTA-loaded cells. These results suggest that an increase in postsynaptic calcium is required for the induction of mossy fiber LTP.
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