Long-term Patient-Reported Outcomes in Older Breast Cancer Survivors: A Population-Based Survey Study

Abstract

For older women with breast cancer, local therapy options may include lumpectomy plus whole-breast irradiation (Lump+WBI), lumpectomy plus brachytherapy (Lump+Brachy), lumpectomy alone (Lump alone), mastectomy without radiation therapy (Mast alone), and mastectomy plus radiation therapy (Mast+RT). We surveyed a population-based cohort of older breast cancer survivors to assess the association of local therapy with long-term quality-of-life outcomes. We used nationally comprehensive Medicare claims to identify women aged ≥67years in whom nonmetastatic breast cancer was diagnosed in 2009, who were treated with 1 of the 5 aforementioned treatment options, and who were still alive in 2015. From this cohort, 1650 patients (330 patients per treatment) were randomly selected. A survey that included the CanSORT (Cancer Surveillance and Outcomes Research Team) Satisfaction with Breast Cosmetic Outcome, BREAST-Q, Decisional Regret Scale, and EQ-5D-3L was mailed to potential participants.We used multivariable linear regression to assess associations between local therapy and outcomes after adjusting for patient, disease, and treatment covariates. Among the 489 women who returned the surveys (30% response rate), the median age at diagnosis was 72years (range, 67-87years). The interval from diagnosis to survey completion was approximately 6years for all patients. Compared with Lump+WBI (adjusted score, 3.40), the CanSORT cosmetic satisfaction scores were higher for Lump+Brachy (score, 3.77; P = .007) and Lump alone (score, 3.80; P = .04) and lower for Mast+RT (score, 3.01; P = .006). Similar trends were seen for BREAST-Q cosmetic satisfaction. BREAST-Q psychosocial, sexual, and physical well-being and EQ-5D-3L global health status tended to be better in patients treated with less irradiation and less surgery.BREAST-Q adverse radiation effects were worse for Lump+WBI compared with Lump+Brachy. Decisional regret regarding surgery and radiation therapy did not differ across groups. Compared with patients treated with Lump+WBI, patients treated with Lump+Brachy and Lump alone reported slightly higher rates of in-breast recurrence (excess risk of 5.8% and 6.4%, respectively; P = .01). In this nationally diverse cohort, less irradiation and less surgery were associated with better long-term quality-of-life outcomes. However, patient regret regarding surgery and radiation therapy was similar across all groups.