Abstract
Materials/Methods: A meta-analysis of observational studies was conducted. Studies eligible for inclusion reported data where all subjects (or subgroups): (1) were diagnosed with pure DCIS, (2) had a minimum median/mean follow-up of 10 years, (3) had details provided on type of surgery (mastectomy, breast conservation or biopsy only) and radiation therapy (RT) received, and (4) had ipsilateral local recurrence (ILR) by local treatment reported. All published studies were considered; no language, publication date or study-type restrictions were imposed. Evaluation of the heterogeneity of all studies, individually and by treatment type, and the calculation of the pooled proportions (overall and by treatment type) was undertaken by variance weighting according to the method described by Berry for small numbers. Fixed or random effects models were used as appropriate with confidence intervals (95% CIs) of pooled proportions derived from the normal approximation of the binomial.
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