Abstract

Study questionThe Cardiovascular Health Awareness Program (CHAP) cardiovascular risk reduction program consisted of sessions run by local volunteers in local pharmacies during which cardiovascular risk was assessed, healthy lifestyle and preventive care was promoted, and the participants were oriented to local resources to support changes in modifiable risk factors. A clustered randomized trial implemented in September 2006 across 39 communities targeting community-dwelling individuals 65 years and older showed a significant reduction in hospitalization one year after its implementation (rate ratio of 91 [95% confidence interval (CI): 86%-97%]). This study explores the impact of CHAP in the first five years.MethodsUsing health administrative data housed at the Institute for Clinical Evaluative Sciences, we established a closed cohort consisting of all individuals eligible in these communities at the study onset whom we followed over time. We assessed hospitalizations and survival using a negative binomial model for count data and Cox regression to assess time to first event, accounting for the clustered design. The primary outcome was the rate of cardiovascular-related hospitalizations defined as congestive heart failure, stroke or acute myocardial infarction.ResultsMost estimates pointed to an advantage for the intervention arm, but only all-cause mortality reached statistical significance (hazard ratio [95% CI] = 0.955 [0.914–0.999]). The hospitalization cardiovascular-related hospitalization rate ratio was (0.958, 95% CI: 0.898–1.022) in favour of the intervention communities, translating to an estimated 408 averted hospitalizations over the five-year period. There was no evidence of the effect of time from start of intervention.ConclusionsThe consistent direction of the outcomes in favour of the intervention arms suggests that CHAP likely had a meaningful impact on reducing cardiovascular-related morbidity and mortality. Given the low cost of the intervention, further development of CHAP should be pursued.

Highlights

  • According to the recently published Global Burden of Disease Study, [1] high blood pressure (BP) is linked to the highest risk of morbidity and premature death worldwide.[2,3,4] The lifetime residual risk of developing hypertension in adults ages 55 to 65 years is estimated to be 90%,6 making high BP a concern for virtually everyone

  • Using health administrative data housed at the Institute for Clinical Evaluative Sciences, we established a closed cohort consisting of all individuals eligible in these communities at the study onset whom we followed over time

  • The hospitalization cardiovascular-related hospitalization rate ratio was (0.958, 95% confidence interval (CI): 0.898–1.022) in favour of the intervention communities, translating to an estimated 408 averted hospitalizations over the five-year period

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Summary

Methods

Using health administrative data housed at the Institute for Clinical Evaluative Sciences, we established a closed cohort consisting of all individuals eligible in these communities at the study onset whom we followed over time. We assessed hospitalizations and survival using a negative binomial model for count data and Cox regression to assess time to first event, accounting for the clustered design. Interested researchers would be able to access the data in the same manner as the authors. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript This does not alter our adherence to all the PLOS ONE policies on sharing data and materials

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