Long-term outcomes of children treated with continuous renal replacement therapy

Abstract

Abstract Introduction The objective of this study is to analyse long-term outcomes and kidney function in children requiring continuous renal replacement therapy (CRRT) after an acute kidney injury episode. Patients and methods A retrospective observational study was performed using a prospective database of 128 patients admitted to the paediatric intensive care unit between years 2006 and 2012 who required CRRT. The subsequent outcomes were assessed in those surviving at hospital discharge. Results Of the 128 children who required CRRT in the paediatric intensive care unit, 71 survived at hospital discharge (54.4%), of whom 66 (92.9%) were followed up. Three patients had chronic renal failure prior to admission to the PICU. Of the 63 remaining patients, 6 had prolonged or relapses of renal function disturbances, but only one patient with atypical hemolytic uraemic syndrome developed end-stage renal failure. The rest had normal kidney function at the last check-up. Conclusions Most of surviving children that required CRRT have a positive outcome, presenting low mortality rates and recovery of kidney function in the medium term.