Long-term outcomes following thrombectomy for acute ischemic stroke in patients with a left ventricular assist device: a case series and literature review

Abstract

Left ventricular assist devices (LVADs) were developed for the treatment of patients with severe heart failure (HF) as a bridge to heart transplantation (HT). Although long-term LVAD support results in substantial improvements, their long-term use often leads to severe acute ischemic stroke (AIS). Serious neurological events make it difficult to continue LVAD support, and these patients are excluded as candidates for HT. AIS remains a challenging problem in patients receiving LVAD support. Recently, although thrombectomy has been established in selected patients who are independent, it has not been established in patients who are not completely independent, such as those with LVAD support. We describe four AIS patients with severe HF who were implanted with an LVAD as a bridge to HT. Five mechanical thrombectomies were performed for AIS associated with an LVAD in four patients. A literature review is presented and compared to the present results. Good recanalization was achieved in all patients. In three cases, marked neurological improvement was observed, and modified Rankin Scale (mRS) scores were maintained without deterioration. The median total follow-up period was 592days. In one patient, HT was successfully performed after thrombectomy. Currently, two of the patients without neurological deficits are awaiting HT. Embolism is a major problem encountered by patients under LVAD support while waiting for an HT. Thrombectomy for AIS associated with LVAD support is a useful and safe treatment modality. It is possible to maintain a reasonable mRS score in patients who are not completely independent.