Abstract
The aim of this study is to describe the effectiveness and safety of nicotine replacement therapy (NRT) in 75 pregnant smokers. The cessation rate was 28% after 1 month, and 13% 1 year after delivery. The side-effects of NRT were transitory. Complications to pregnancy were similar in the NRT group and a comparable group. Nicotine replacement products used included either 2mg nicotine gum, or a 15mg nicotine patch (16 hours/day), or both. The individual therapy was decided on the level of nicotine dependence, as measured by the Fagerström score. The concentration of cotinine in saliva and carbon monoxide in expired air was lower when the women used NRT than when they smoked. For women using either nicotine patch or patch plus gum, the mean saliva concentration of cotinine was significantly reduced (p<0.001). For women using only gum, the reduction was borderline significant (p=0.06).
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