Long-term neuro-functional disability in adult patients with community-acquired bacterial meningitis.

Abstract

To investigate the prevalence of neuro-functional disability and its determinants 12months after community-acquired bacterial meningitis (CABM) in adult patients. In a prospective multicenter cohort study (COMBAT), all consecutive cases of CABM were enrolled and followed up for 12months. Neuro-functional disability at 12months was evaluated using a combination of the Glasgow Outcome Scale (functional disability), and the modified Rankin Disability Scale (physical disability). Factors associated with neuro-functional disability were identified by multivariate logistic regression. Among 281 patients, 84 (29.9%) patients exhibited neuro-functional disability at 12months: 79 (28.1%) with functional disability and 51 (18.1%) with physical disability. Overall, 6 patients (2.1%) died during the follow-up. The most common pathogen identified was Streptococcus pneumoniae (131/272, 48.2%); 77/268 patients (28.7%) had a physical disability at hospital discharge. Factors independently associated with 12-month neuro-functional disability were a pneumococcal meningitis (adjusted OR = 2.8; 95% confidence interval (CI) = [1.3; 6.7]), the presence of a physical disability at hospital discharge (aOR = 2.3; 95%CI = [1.2; 4.4]) and the presence of behavioral disorders at hospital-discharge (aOR = 5.9; 95%CI = [1.6; 28.4]). Dexamethasone use was not significantly associated with neuro-functional disability (OR = 0.2; 95%CI = [< 0.1;1.3]). Neuro-functional disability is frequently reported 12months after CABM. Detailed neurological examination at discharge is needed to improve the follow-up. NCT01730690.