Abstract
It has been suggested that exercise improves cognitive function and increases cerebral volume even in older people. However, the relation between cognitive function and brain volume is unclear. We evaluated the longitudinal change of cognitive function and gray matter volume due to mild-intensity exercise over 2 years, and the residual effects 6 months post-exercise. Subjects were 110 healthy older individuals over 65 years old in Tone town, Ibaraki prefecture. Seventy-five participants were voluntarily enrolled in the exercise group. A mild-intensity calisthenics regimen, which consisted of home-based and club-based programs for as long as 2 years, was employed as the intervention for the exercise group. The exercise group showed significant improvement in attentional shift over the course of the observation period including a 6-month follow-up. Neuroimaging analysis revealed the significant preservation of bilateral prefrontal volume in the exercise group with small-volume corrections, although this effect faded after intervention. Furthermore, the longitudinal changes in attentional shift and memory were positively correlated with the prefrontal volumetric changes. Our results suggest that mild-intensity exercise could prevent prefrontal volume reduction due to aging and impede cognitive decline.
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