Abstract
Background:The shortage of transplantable organs has led to the expansion of the living kidney donor (LKD) pool to include overweight (body mass index [BMI] 25-30 kg/m2) and obese (BMI ≥30 kg/m2) donors. Higher BMI is a known risk factor for chronic kidney disease and progression to end-stage renal disease.Methods & Materials:We focused our review on long-term kidney-related outcomes (kidney function, hypertension, and proteinuria) among higher BMI LKDs. A PubMed search retrieved a total of 27 articles reporting on renal outcomes for obese LKDs. Of these, nine studies with ≥5 years of follow-up were selected for inclusion.Results:Five studies reported a decrease in kidney function at follow-up for higher BMI LKDs. Higher BMI was noted as a risk factor for hypertension in six studies. Proteinuria was reported in six studies, and a significant association was noted with higher BMI status in three.Conclusion:This review highlights the continued need for long-term documentation of kidney function and related outcomes in higher BMI LKDs.
Highlights
Chronic kidney disease (CKD) is a major public health problem
Methods & Materials: We focused our review on long-term kidney-related outcomes among higher BMI living kidney donor (LKD)
Five studies reported a decrease in kidney function at follow-up for higher BMI LKDs
Summary
Chronic kidney disease (CKD) is a major public health problem. It is defined by the National Kidney Foundation as the presence of glomerular filtration rate (GFR) ≤60 mL/min for ≥3 months, pathological abnormalities or markers of kidney damage in blood or urine, or by abnormalities on imaging tests. Patients with end-stage renal disease (ESRD) on dialysis carry an increased risk of cardiovascular and cerebrovascular disease-related morbidity and mortality [3]. Kidney transplantation (deceased and living donor) has paved way for better outcomes and quality of life for individuals with ESRD. It is well known that the wait-time for deceased donor kidneys has greatly increased. Higher BMI is a known risk factor for chronic kidney disease and progression to end-stage renal disease
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