Abstract
Purpose: To study the influence of prepubertal unilateral testicular torsion on spermatogenesis postpubertally. Methods: Sixty prepubertal SD male rats were divided into 6 groups. In each group, animal suffered different courses of unilateral testicular torsion including sham operation, 2- and 6-hour-long torsion, and permanent torsion. Salvia miltiorrhiza was injected as a remedy to release the I/R injury in the 2- and 6-hour-long torted groups. Postpubertally, the percentage of DNA content of haploid cells in the testes was determined individually. Results: The percentage of haploid cells in the sham operation group was 76.5 ± 1.9%. The number decreased in every other group (p < 0.01). Comparing with the same course of torsion, Salvia miltiorrhiza injection could improve the percentage of haploid cells (p < 0.01). In the permanent unilateral testicular torted group, the percentage was nearly zero (0.4 ± 0.2%). Conclusions: Prepubertal unilateral testicular torsion induces decreased spermatogenesis postpubertally. The result takes place in the bilateral testes. Salvia miltiorrhiza, as an antioxidant remedy, could relieve the injury which manifests improved spermatogenesis.
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