Abstract
The long-term clinical and radiological outcomes of dental implants inserted in augmented bone treated with platelet-rich plasma (PRP) has not been well addressed in the literature yet. This study is based on a collection of patients from a randomized controlled trial (RCT) that did not report any short-term positive effects of PRP on bone healing after sinus lift surgery using autologous iliac crest bone graft. This study aimed to evaluate the long-term impact of PRP regarding clinical and radiological outcomes on the inserted implants in the previous RCT. For this evaluation, we considered the following variables: plaque index, probing depth, bleeding index, mobility grade, Periotest® values, and radiological bone loss. Out of 53 patients (n = 306 implants) included in the previous study we were able to reinvestigate 37 patients (n = 210 implants) in two centers (31 in Giessen, Germany and 6 in Erlangen, Germany). Clinical and radiographic parameters suggested overall healthy conditions of the peri-implant tissue. The PRP-group and the control group did not differ significantly in the majority of the parameters. The overall evaluation showed that result data of the PRP-group was inferior to the control group in 64 percent of the evaluated parameters. The present study cannot provide evidence of a positive effect of PRP on the long-term implant clinical and radiological outcomes. In fact, a tendency towards inferior long-term results in the PRP-group was detected without reaching a significant threshold. Further controlled trials need to be conducted to investigate this correlation.
Highlights
Dental implants have high survival probabilities with good clinical and radiological findings [1]
The long-term clinical and radiological outcomes of dental implants inserted in augmented bone treated with platelet-rich plasma (PRP) has not been well addressed in the literature yet
This study is based on a collection of patients from a randomized controlled trial (RCT) that did not report any short-term positive effects of PRP on bone healing after sinus lift surgery using autologous iliac crest bone graft
Summary
Dental implants have high survival probabilities with good clinical and radiological findings [1]. Long-term studies documented a survival rate of approximately 95% over a study period of at least ten years [2,3]. One of the important factors leading to late implant loss is peri-implantitis, which is a combination of mucositis and bone resorption around implants [4,5,6]. Studies have reported a correlation between autologous cancellous bone grafts and long-term bone resorption, which leads to peri-implantitis and consecutive implant loss [8,9]. Bone loss resulting from trauma, disease, aging, or congenital abnormalities, remains a global challenge for health professionals and patients. Maxillofacial or craniofacial bone loss has a high psychological impact on patients. Aesthetic reconstruction is as valuable as functional reconstruction in this region [10]
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