Abstract
An essential criterion for the selection of resorbable bioceramics is their ability to degrade inside human body within a reasonable time frame. Furthermore, if the bioceramic can release beneficial ions, such as strontium, as it degrades, recovery time might be shortened. The present study demonstrates that strontium-containing calcium sulfate (Sr,Ca)SO4 can fulfill these criteria. A long-term in vitro degradation analysis for 12 weeks using sintered (Sr,Ca)SO4 discs in phosphate buffered solution (PBS) was conducted. The sintered (Sr,Ca)SO4 disc was then implanted into defects in the distal femur of rats. The degradation rate of (Sr,Ca)SO4 discs showed a strong dependence on the Sr content. Similar results were observed between the long-term in vitro degradation analysis and the in vivo evaluation. The sintered (3.8%Sr,Ca)SO4 disc lost more than 80% of its initial weight after soaking in PBS with shaking at 37 °C for 12 weeks. After 12 weeks in vivo, the remaining volume of the (3.8%Sr,Ca)SO4 disc within the bone defect was ~25%. Over the same time period, new bone was formed at a relative volume of 40%. This study demonstrates the potential of (Sr,Ca)SO4 bioceramic, and the benefits of using a long-term degradation test during the evaluation of resorbable bioceramics.
Highlights
The development of bioceramics is intended to reduce pain by shortening the healing time of patients; extensive in vitro and in vivo testing is required before bioceramics can become widely available
The present study focused on the degradation behavior of bioceramics in fluid
Resorbable bioceramics have been developed with the goal of shortening the healing time for patients with bone defects
Summary
The development of bioceramics is intended to reduce pain by shortening the healing time of patients; extensive in vitro and in vivo testing is required before bioceramics can become widely available. Due to the numerous tests, the development of novel materials for bone grafts is a costly and time-consuming process. Many medical needs are still currently unmet. The defect left behind after the removal of a musculoskeletal sarcoma is usually large [1]. The time needed to heal such large bone defects is at least 3–6 months. The time needed is even longer [2]. There is a need to develop bone grafts that can reduce the healing time for bone defects
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