Abstract
BackgroundGlioma diagnosis can be devastating and result in a range of symptoms. Relatively little is known about the long-term health-related quality of life (HRQOL) challenges faced by these patients. Establishing the impact of diagnosis on HRQOL could help positively tailor clinical decision making regarding patient support and treatment. The aim of this review is to identify the long-term HRQOL issues reported at least 2 years following diagnosis of WHO grade II/III glioma.MethodSystematic literature searches were carried out using Medline, EMBASE, CINAHL, PsycINFO, and Web of Science Core Collection. Searches were designed to identify patient self-reports on HRQOL aspects defined as physical, mental, or social issues. Quality assessment was conducted using the Mixed Methods Appraisal Tool (MMAT). Narrative synthesis was used to collate findings.ResultsThe search returned 8923 articles. Two hundred seventy-eight titles remained after title and abstract screening, with 21 full-text articles included in the final analysis. The majority of studies used quantitative methods, with 3 articles reporting mixed methodology. Negative emotional/psychological/cognitive changes were the most commonly reported. Physical complaints included fatigue, seizures, and restricted daily activity. Social challenges included strained social relationships and financial problems. Patient coping strategies were suggested to influence patient’s survival quality.ConclusionThe consequences of a glioma diagnosis and treatment can have substantial implications for patients’ long-term HRQOL and daily functioning. Findings from this review lay the groundwork for efforts to improve patient HRQOL in long-term survivorship.
Highlights
Gliomas account for 78% of primary malignant brain tumours[1], with astrocytomas and oligodendrogliomas making up 16.7% and 4.5% of these respectively [2]
This left 2902 titles. 2624 articles were excluded based on title/abstract screening, as they did not meet the inclusion criteria. 278 articles were assessed in full for eligibility, removing 219 articles that did not meet the inclusion criteria. 41 articles appeared relevant; eight were excluded after full-text review with 14 lacking details needed to ipt determine check against the inclusion/exclusion criteria
The present review found that glioma patients‟ self-reported cognitive issues are of considerable importance across their long-term survival
Summary
Gliomas account for 78% of primary malignant brain tumours[1], with astrocytomas and oligodendrogliomas making up 16.7% and 4.5% of these respectively [2] Gliomas and their treatment can result in noticeably impaired health-related quality of life (HRQOL)[3]. Survival ranges from 4-16 years following initial u diagnosis [6], and patients receive multimodal treatments primarily with the aim of delaying disease n progression and extending survival Given this prognosis, consideration of HRQOL in long-term a survival is of increasing importance in both clinical and social care settings for patients with WHO M grade II and III gliomas. The aim of this review is to identify the long-term HRQOL c issues reported at least two years following diagnosis of WHO grade II/III glioma. Patient coping strategies were suggested to influence patient‟s survival quality
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