Long-term graft function of adult rat islets after transplantation in immunocompetent diabetic mice treated with donor specific splenocytes and anti-CD154 monoclonal antibody

Abstract

Aim: Combined treatment with a single donor specific transfusion (DST) and a brief course of anti-mouse CD154 monoclonal antibody (mAb) to induce co-stimulation blockade leeds to long-term islet allograft survival in mice. We hypothesized that this protocol could also induce long-term graft survival of adult rat islets in immunocompentent diabetic mice.