Abstract

Background: Patients with a regrowth in a wait-and-see-program are reported to have a higher risk for metastases. This is probably related to an inherent higher risk of incomplete responders, but it cannot be excluded that metastases can arise from the regrowth. The aim of this study was to evaluate the risk of distant metastasis in wait-and-see patients with a clinical(near)complete response (cCR) after neoadjuvant chemoradiation (CRT) for rectal cancer, according to local regrowth and timing of inclusion.

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