Abstract

Summary The clinical characteristics of patients triply infected with HIV, HBV and HCV are notable. From January 2005 to June 2014, a total of 115 cART-naive HIV/HBV/HCV infected individuals were studied and 91 of them were followed-up consecutively after cART with 3TC. After cART with 3TC, the HBV-DNA positive rate decreased from 37.4% (43/115) to 9.9% (9/91) (P<0.001), whereas the HCV-RNA positive rate increased from 53.9% (62/115) to 70.3% (64/91) (P=0.016), and HCV-RNA level increased from 3.52 log10 copies/ml to 4.81 Log10 copies/ml (P=0.012). The occurrence of end-stage liver diseases (ESLDs) increased from 6.1% (7/115) to 18.7% (17/91) (P=0.005), and the occurrence of HCV-related ESLDs increased from 0.9% (1/115) to 14.3% (13/91) (P=0.001) whereas the proportion of HBV-related ESLDs decreased from 85.7% (6/7) to 23.5% (4/17) (P=0.005). Along with the initiation of 3TC-based cART, HCV-related liver diseases have become the leading challenge among HIV/HBV/HCV infectied patients. This article is protected by copyright. All rights reserved.

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