Abstract
The amounts of gonadotrophins in 24 h urines (U-LH, U-FSH) reflect spontaneous gonadotrophin secretion and should be taken as a good marker of the onset of puberty. Thirteen cases of precocious puberty (10 girls and 3 boys) have been treated with monthly IM injections of a long acting D-TRP-6 LHRH (DECAPEPTYL). 24 h urines are collected on days 15 and 30 following each injection. In every case, the efficiency of treatment was certified by the decrease of clinical manifestations, growth velocity, uterine size, plasma levels of testosterone and with no response to LHRH test (J. Clin. Endocrinol. Metab., 1986, 4, 670). In both sexes, after a short rise, U-LH rapidly fall to prepubertal levels and remained unchanged thereafter. In girls, U-FSH decreased dramatically during the first month (p 2.14 IU/24 h) and a bone age > 12 yrs. In boys, this escape of U-FSH has not been observed. Our data show the usefulness of UG excretion in LHRH treatment of precocious puberty. But in bone age > 12 yrs an increase of U-FSH without any clinical relapse suggests a selective escape of desensitization of FSH which could be taken as an index of hypothalamo-pituitary maturation and therapeutic interruption.
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