Abstract
Multiple hepatic vessels and portal vessels are distributed in the central segments of the liver (segments IV, V and VIII). Due to its anatomical complexity, in centrally-located hepatocellular carcinoma (cHCC) it is theoretically not easy to reach a wide margin, as it is in non-central hepatocellular carcinoma (ncHCC) (segments II, III, VII and VIII). We compared their outcomes to see if cHCC has an inferior result than ncHCC. From August 2000 to July 2008, 213 HCC patients received curative-intended resection. Sixty-nine cHCC (group A) and 64 ncHCC (group B) received trisegmentectomy (include mesohepatectomy), bi-segmentectomy, mono-segmentectomy or subsegmentectomy. The outcomes were retrospectively analyzed. The in-hospital mortality was 0% and 3.12% in groups A and B, respectively (p=0.55). The morbidity was 27.5% and 28.1% in groups A and B, respectively (p=0.23). The 1- and 3-year disease-free survival were 68%, 50% and 62%, 33% in groups A and B, respectively (p=0.39). The 1- and 3-year overall survival rates were 83%, 75% and 89%, 70% in groups A and B, respectively (p=0.91). Tumor size and numbers were significant factors for disease-free and overall survival. cHCC treated by partial hepatectomy and mesohepatectomy has a comparable result to ncHCC. Mesohepatectomy is needed only in some selected patients.
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