Abstract

The neurocognitive basis of the effect of long-term high altitude exposure on conflict control is unclear. Event related potentials (ERPs) were recorded in a flanker task to investigate the influence of high altitude on conflict control in the high-altitude group (who had lived at high altitude for three years but were born at low altitude) and the low-altitude group (living in low altitude only). Although altitude effect was not significant at the behavioral level, ERPs showed cognitive conflict modulation. The interaction between group and trial type was significant: P3 amplitude was greater in the low-altitude group than in the high-altitude group in the incongruent trial. This result suggests that long-term exposure to high altitude affects conflict control in the conflict-resolving stage, and that attentional resources are decreased to resist the conflict control in the high-altitude group.

Highlights

  • In recent years, the rapid expansion of lowland Chinese population into the western part of China has led to about 6 million Han lowland immigrants living Qinghai-Tibetan Plateau permanently as of 2006 [1]

  • The results showed that a conflict control effect was successfully elicited, as reflected by behavior and Event related potentials (ERPs) results, with longer reaction time, higher error rates, larger N2 amplitude, and longer P3 latency in the incongruent trials than in the congruent trials

  • SpO2 decreased in the high altitude group, which suggests that the subjects were suffering from hypoxia

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Summary

Introduction

The rapid expansion of lowland Chinese population into the western part of China has led to about 6 million Han lowland immigrants living Qinghai-Tibetan Plateau permanently as of 2006 [1]. Living at such a high altitude causes a reduction of partial pressure of inspired oxygen and lower hemoglobin oxygen saturation (%SpO2), which can lead to hypoxia [2, 3], and affects cognition [4]. In the electrophysiological study, the PLOS ONE | DOI:10.1371/journal.pone.0145246 December 15, 2015

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