Abstract

PURPOSE: Clara Cells (CC), non-ciliated epithelial cells prominent in bronchioles, produce a specific protein (CC10) in response to diverse injurious stimuli to the respiratory system. We previously reported an acute increase in CC10 in rat lungs following IV triolein injection in a model of lung damage similar to Fat Embolism Syndrome (FES) in humans. The bronchial and septal CC staining peaked at 24hr post-injection, associated with septal inflammation, fibrosis, bronchitis and vasculitis, persisting at 96hr but with improvement at 264hr.

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