Long-term effects of the daily wear of senofilcon A silicone hydrogel contact lenses on corneal and conjunctival tissues

Abstract

Purpose The objective of the investigation was to show that, because of their overall properties, Acuvue ® Oasys™ with Hydraclear ® Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term daily wear. Methods The 2-year investigation was a prospective daily wear analysis of Acuvue ® Oasys™ with Hydraclear ® Plus (senofilcon A) silicone hydrogel contact lenses replaced every 2 weeks and used in conjunction with a representative range of care systems. Results The 2-year results compared with the subjects' baseline ocular status on entering the study revealed: • For new wearers, there was no change in the limbal zone and significant improvement in the bulbar area, both in terms of hyperemia and staining and in corneal staining. • For established contact lens wearers, there was an improvement in all 3 characteristics. Conclusions The quantification of the effects on the ocular tissues of 2 years of daily wear of senofilcon A, by mainly previously successful daily soft contact lens wearers, showed an excellent biocompatibility. The results support the hypothesis that senofilcon A contact lenses, when worn on a 2-week daily wear regimen, maintain excellent long-term ocular tissue tolerance.