Abstract
The aim of this study to evaluate histopathological improvement and virological, serological and biochemical response rates in patients with chronic hepatitis B (CHB) who were treated with tenofovir disoproxil fumarate (TDF). A total of 91 nucleosid(t)e-naive CHB patients who received TDF were evaluated. Virological, serological and biochemical test results were assessed at baseline and every 12 weeks. Liver biopsy specimens were assessed according to the modified Ishak scoring. The study was conducted on 52 patients. The mean age was 40±10 years and 40.4% were female. The mean follow-up period was 33±11 months. HBsAg seroclearance occurred in none of the patients. The serum level of HBV-DNA became undetectable in 94.2% of the patients. Mean histological activity index at baseline and on-treatment were 8.2±2.3 and 6.2±2.0 and the mean fibrosis scores were 2.65±1.3 and 2.33±1.1, respectively. We determined that TDF therapy provided remarkably good HBV DNA suppression and biochemical response rates, but low seroconversion. Improvement of liver necroinflammation was detected, but no significant change observed in fibrosis.
Highlights
Despite immunization programs for hepatitis B infection, chronic viral hepatitis B (CHB) infection remains an important public health problem
We determined that Tenofovir disoproxil fumarate (TDF) therapy provided remarkably good HBV DNA suppression and biochemical response rates, but low seroconversion
Tenofovir disoproxil fumarate (TDF) is the acyclic phosphonatediesther analog of adenosine monophosphate (3,4) and its high genetic barrier against the mutations in DNA polymerase suggests that less problem will be encountered in terms of resistance (5)
Summary
The study was conducted on 52 patients. The mean age was 40±10 years and 40.4% were female. Mean histological activity index at baseline and on-treatment were 8.2±2.3 and 6.2±2.0 and the mean fibrosis scores were 2.65±1.3 and 2.33±1.1, respectively
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