Abstract

MgSO4 has been used for the last two decades as a neuroprotective treatment in a variety of preterm conditions. Despite the putative advantages of MgSO4 as a neuroprotective agent in the preterm brain, the long-term molecular and behavioral function of MgSO4 as a neuroprotective agent has not been fully elucidated. The objectives of this study were to investigate the long-term effect of antenatal MgSO4, during late gestational, on offspring’s behavior in a mouse maternal immune activation (MIA) model in adolescence and adulthood, and to explore its influence on brain gene expression (e.g., ErbB signaling, pro-inflammatory and dopaminergic markers) in adulthood

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