Abstract
Retinoblastoma is the most common intraocular neoplasm of childhood which is caused by a defective RB1 gene. It is detected early in life by clinical presentation including leukocoria, strabismus, glaucoma, poor visual tracking, and inflammation among others. Antineoplastic therapy that children with childhood malignancies are submitted to, have long-term effects on various tissues in the body. With timely treatment, the 5 years survival rate for retinoblastoma is reported to be 99%. Dental anomalies commonly seen in these children are characterized by disturbances in shape, size, number, and mineralization in permanent teeth. The purpose of this case report is to present long-term effects of chemotherapy and radiotherapy on dental development in a patient treated for retinoblastoma in childhood and discuss its pathogenesis. Early diagnosis of presence and severity of dental anomalies will help the dentist to plan and implement an appropriate course of dental treatment to make the survivor child's life as normal as possible.
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