Abstract
ObjectiveThe long-term coronary arterial response of biodegradable polymer biolimus-eluting stents (BES) remains unclear. We sought to evaluate the coronary arterial response of biodegradable polymer BES at 5 years after stent implantation using optical coherence tomography (OCT) as compared with that of durable polymer sirolimus-eluting stents (SES) and bare-metal stents (BMS). MethodsFive-year follow-up OCT was performed in 30 patients with 33 stents (10 with 12 BES; 10 with 11 SES; 10 with 10 BMS). Quantitative parameters and qualitative characteristics of the neointima were evaluated. A total of 5178 struts (BES, n = 2056; SES, n = 1410; BMS, n = 1712) were analyzed. ResultsUncovered struts were found in 15 out of 2055 struts in the BES (weighted estimate 0.01%, 95% confidence intervals [CI]: 0.00–0.33%) and 54 out of 1410 struts in the SES (0.11%, 95% CI: 0.00–3.33%) (odds ratio [OR] 0.12, 95% CI: 0.01–1.95, p = 0.13). None of 1712 struts were uncovered in the BMS. Cross-sectional qualitative analysis of neointimal tissue showed that the frequency of lipid-laden neointima tended to be lower in the BES (2.26%, 95% CI: 0.38–12.3%) compared with the SES (9.90%, 95% CI: 4.37–20.9%; OR 0.21, 95% CI 0.03–1.16, p = 0.07), and was similar to the BMS (2.23%, 95% CI: 0.54–8.74%; OR 0.98, 95% CI 0.13–7.14, p = 0.98). ConclusionsBiodegradable polymer BES shows a favorable coronary arterial response compared with SES, but different response with BMS at 5 years follow-up. The observed frequency of in-stent neoatherosclerosis within BES was similar to BMS and tended to be lower than SES.
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