Abstract
BackgroundTreatment recommendations for gastric mucosa-associated lymphoid tissue (MALT) lymphoma are based on case series and expert opinions. Only a few previous studies have focused on the long-term outcomes of gastric MALT lymphoma, especially according to stage.MethodsPatients diagnosed with gastric MALT lymphoma from January 2000 to December 2018 at nine university hospitals in Korea were included. Clinical data of medical history, endoscopic features, histological diagnosis, results of Helicobacter pylori (H. pylori) testing, stage, treatment conditions, and outcomes were collected.ResultsA total of 1,163 patients was enrolled, and 97.6% (n=1,038) of patients were diagnosed as stage IE. 10-year overall survival (OS) for the entire population was 99.1% and was better for patients in stage IE compared with patients in stage III/IV (p=0.002). The 10-year OS for H. pylori-positive patients was better than that of H. pylori-negative patients (p=0.022). Multivariate analyses revealed initial stage III/IV as a prognostic factor associated with over-all survival.ConclusionThe majority of gastric MALT lymphoma patients are diagnosed at an early localized stage in Korea. The overall survival rate of gastric MALT lymphoma is excellent and is associated with the initial stage of the disease.
Highlights
Extranodal marginal zone B-cell lymphoma of mucosaassociated lymphoid tissue (MALT), known as MALT lymphoma, arises from malignant transformation of B cells from the marginal zone of MALT [1]
A total of 1,280 patients was diagnosed with gastric MALT lymphoma during the study period (Figure 1)
Earlier studies reported that 5-year overall survival (OS) and disease-free survival (DFS) rates were as high as 90% and 75%, respectively, when lymphoma was treated at an early stage [24]
Summary
Extranodal marginal zone B-cell lymphoma of mucosaassociated lymphoid tissue (MALT), known as MALT lymphoma, arises from malignant transformation of B cells from the marginal zone of MALT [1]. Few studies have reported the treatment and survival of patients according to their different stages [18, 19]. Most previous studies that reported gastric MALT lymphoma survival rates included small population sizes. Understanding the survival rates of gastric MALT lymphoma patients according to stage should aid in improving therapeutic strategies. We evaluated treatments and long-term outcomes based on gastric MALT lymphoma stage in Korean patients. We examined the survival rates of gastric MALT lymphoma patients according to stage and H. pylori infection status. Treatment recommendations for gastric mucosa-associated lymphoid tissue (MALT) lymphoma are based on case series and expert opinions. A few previous studies have focused on the long-term outcomes of gastric MALT lymphoma, especially according to stage
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