Abstract
I read with interest and congratulations the results of “Long-Term 3T MR Angiography Follow-Up after Therapeutic Occlusion of the Internal Carotid Artery to Detect Possible de Novo Aneurysm Formation,”[1][1] as well as the opinion regarding management of internal carotid artery (ICA) aneurysms
Highlights
Computer-Based 3D MR Imaging Analysis in Amyotrophic Lateral Sclerosis: Common and Specific Factors Among Studies Computerized MR imaging analysis including automatic measurements of whole-brain atrophy and the use of unbiased analysis techniques for regional atrophy without prior restriction of the search volume is a rapidly growing field in neuroimaging
Mezzapesa et al[1] reported global brain atrophy in a group of 16 patients with amyotrophic lateral sclerosis (ALS); and in the analysis of local brain changes by VBM in the same patients, they reported gray matter reductions in extramotor areas, including the bilateral frontal and temporal lobes. Both with respect to the global brain atrophy measure and to the regional findings, additional comparisons with previous 3D MR imaging studies in ALS are necessary beyond those discussed by Mezzapesa et al In a previous study of 22 patients with definite ALS,[2] BPF assessment by use of the same technical approach but a different software solution came to the same result of a highly significant global brain atrophy compared with 22 age-matched controls
It is remarkable that this effect could only be observed in the analysis of BPF as the size-normalized proportion of brain parenchymal volume to total intracranial volume, whereas neither the calculation of normalized brain volume in the same study[1] nor the absolute volume measurements in non-normalized 3D MR imaging data of ALS patients[3] nor the earlier MR imaging studies cited by Mezzapesa et al[1] led to significant group differences between ALS brains and those of controls
Summary
Computer-Based 3D MR Imaging Analysis in Amyotrophic Lateral Sclerosis: Common and Specific Factors Among Studies Computerized MR imaging analysis including automatic measurements of whole-brain atrophy and the use of unbiased analysis techniques for regional atrophy without prior restriction of the search volume (such as voxel-based morphometry [VBM]) is a rapidly growing field in neuroimaging.
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