Abstract
Long-term changes in blood pressure were studied to determine the relationship to hypertensive clinical manifestations, and to cerebral infarction. In the prospective cohort study in Hisayama, Japan, the initial 4yr were assigned for assessment of changes in blood pressure. During the subsequent 9 yr from 1965, cerebral infarction developed in 71 (44 men, 27 women) among 1181 subjects, 44-years old or older and fatalities were verified by autopsy. Blood pressure elevation to the hypertensive range contributed to the complications manifested by changes in ocular fundi and/or ECG, and increased the risk of cerebral infarction. However, in the women, a systolic blood pressure decrease greater than the mean − 1 SD, cerebral infarction developed more frequently than in those whose systolic blood pressure remained within mean ± 1 SD. Results of the multiple regression analysis indicated that blood pressure in women prior to cerebral infarction may cover a range of variability.
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