Abstract
Rats were given a continuous subcutaneous infusion of either bupivacaine (n = 18) or placebo (n = 17) for 4 days. On the 5th day the acute seizure threshold to intravenous bupivacaine was determined in both groups. Blood and brain concentrations of bupivacaine at the onset of seizures showed no difference between the two groups, whereas the seizure dose was decreased in the bupivacaine group. The tachyphylaxis observed when bupivacaine is used for a regional nerve blockade does not seem to evolve for the central nervous system effects.
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