Abstract
When treating patients whose depression remits when an atypical antipsychotic is added to an antidepressant, clinicians want to know if the antipsychotic can be stopped because the antidepressant alone prevents relapse. A manufacturer-sponsored study tries to answer this question. In the initial phase, 892 patients with major depression who had failed at least two antidepressants were treated with olanzapine-fluoxetine combination (OFC) for 6 to 8 weeks …
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